On Demand Therapeutics

The ODTx Solution

A Revolutionary Breakthrough in Ophthalmic Drug Delivery

To change the way sight-threatening diseases are treated, an ocular drug delivery system must be efficacious, convenient, and safe - and that's what the On Demand Therapeutic (ODTx™) solution is designed to be. The biocompatible, non-bioerodible ODTx implant is comprised of multiple, sealed reservoirs containing individual doses of drugs to treat retinal diseases. Every reservoir is designed to safely store and maintain the stability of small or large molecule drugs in the eye until an ophthalmologist initiates drug release from one or multiple reservoirs with a laser. By allowing this precise control, ODTx is able to fulfill the unmet need for sustainable and interactive therapies that effectively treat severe retinal diseases.

The ODTx Procedure

The ODTx procedure begins with the injection of the device into the periphery of the vitreous in the region of the pars plana using a standard intravitreal injection technique. When the ophthalmologist decides to release the drug, he/she uses a slit lamp and mirrored lens to locate the ODTx implant and focuses a laser beam on the selected reservoir. When the laser energy hits the selected reservoir, an opening is created that allows the drug contained inside the reservoir to elute into the vitreous and diffuse to the retina. The un-activated reservoirs remain intact and enable the ophthalmologist to release drugs from the additional reservoirs via the same non-invasive process "as needed" during subsequent visits.

The ODTx Benefits

Current drug therapy for retinal disease involves forcing patients to endure monthly intravitreal injections. The ODTx device is designed to provide drug therapy for an extended duration of a year or more. After the initial insertion, follow-up visits involve the non-invasive activation of specific reservoirs with a laser to deliver doses of drug to the patient. ODTx's sealed reservoirs and laser-activation mechanism provide an effective way to deliver protein and other drugs. Other delivery technologies (i.e., bioerodible polymers, pumps, microspheres, screws, drops, etc.) have difficulty delivering such drugs due to issues like drug formulation instability, materials compatibility, and transport limitations. As a result, the ODTx device is more versatile and broadly applicable than any other ocular delivery technology available today.

In addition to the numerous benefits that ODTx technology provides patients, it also provides advantages for ophthalmologists and the ophthalmic therapeutic industry. The ODTx device allows a precise, physician-controlled drug delivery procedure that reduces treatment burdens, enables concomitant therapies, and creates product differentiation through delivery.

For a more streamlined view of ODTx's benefits please view the chart below.